There are over 100 identified cannabinoids in Cannabis Sativa.
BCP is a constituent of the essential oils of numerous spice and food plants and a major component in Cannabis.
Complete CB2 agonist, as opposed to its CBD cousin, which is a partial agonist.
Appropriately dosed to achieve therapeutic effect.
Achieve relief from the following:
- Cortisol management
- Adrenal function
- Acute pain
- Chronic pain
- Anti-inflammatory and immune support
- Aids in stress reduction
- Cardiovascular and neurological function support
- Improves skin for a smoother complexion
- Provides digestion, liver. respiratory and antioxidant support
Contains: (BCP β-Caryophyllene) 600mg/ml
WHAT IS BCP?
β-caryophyllene (BCP), a potent non-psychoactive cannabinoid and a full agonist of the CB2 (cannabinoid type-2) receptor, while cannabidiol (CBD) is only a partial agonist of CB2. BCP is found in the essential oils of the following plants at (Ahmed et al. 2000; Alma et al. 2007; Bernotienë et al. 2004; Calvo-Irabien et al. 2009; Jirovetz et al.2002; Kaul et al. 2003; Leandro et al. 2012; Prashar et al. 2004; Ormeño et al. 2008; Silva et al. 2004; Singh et al. 2006; Vito & Steinemann 1997):
- Marijuana flower at 37.5%
- Capoiba at 35%
- Malabrathum at 25.3%
- Basil at 19.8%
- Clove bud at 19.5%
- Oregano at 15.7%
- Hops at 14.5%
- True cinnamon at 11.1%
- Ylang-ylang at 10.7%
- Rosemary at 8.3%
- Black caraway at 7.8%
- Lavender at 7.55%
- Black pepper at 7.29%
BCP VS CBD
The Ki value of a molecule represents its receptor affinity (strength). The smaller theKi the less molecule is needed, thus, the stronger it is. BCP has a mean Ki = 320nM for CB2, while CBD has a Ki = 2860nM for CB2 (Abcam 2019; Gertsch et al. 2008). This means BCP requires approximately 11 times less molecule to activate the CB2 receptor than CBD. BCP activates 100% of the CB2 receptor, while CBD activates approximately only 60% of the CB2. This makes BCP far superior to CBD.
Abcam. 2019. (-)-Cannabidiol, Natural cannabinoid (ab120448) . Retrieved from https://www.abcam.com/--cannabidiol-natural-cannabinoid-ab120448.html#top-41
Ahmed, A., Choudhary, M. I., Farooq, A., Demirci, B. & Başer, H. C. 2000. Essential oil constituents of the spice Cinnamomum tamala (Ham.) Nees & Eberm. Flavour and Fragrance Journal, 15 (6), pp. 388-390. DOI: 10.1002/1099-1026(200011/12)15:6<388::AID-FFJ928>3.0.CO;2-F
Alma, M. H., Ertaş, M., Nitz, S. & Kollmannsberger, H. 2007. Chemical composition and content of essential oil from the bud of cultivated Turkish clove. BioResources, 2 (2), pp. 265-269. ISSN 1930-2126
Atakan, Z. 2012. Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic Advances in Psychopharmacology, 2 (6), pp. 241-254. DOI: 10.1177/2045125312457586
Bahi, A. Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M. & Ojha, S. 2014. β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiology & Behaviour, 135, pp. 119-124. DOI: 10.1016/j.physbeh.2014.06.003
Basha, R. H. & Sankaranarayanan, C. 2014. β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats. Acta Histochemica, 116 (8), pp. 1469-1479. DOI: 10.1016/j.acthis.2014.10.001
Bento, A. F., Marcon, R., Dutra, R. C., Claudino, R. F., Cola, M., Leite, D. F. & Calixto, J. B. 2011. β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway. The American Journal of Pathology, 178 (3), pp. 1153-1166. DOI: 10.1016/j.ajpath.2010.11.052
Bernotienë, G., Nivinskienë, O., Butkienë, R. & Mockutë, D. 2004. Chemical composition of essential oils of hops (Humulus lupulus L.) growing wild in Auktaitija. Chemija, 2 (4), pp. 31-36. ISSN 0235-7216
Calleja, M. A., Vieites, J. M., Montero-Meléndez, T., Torres, M. I., Faus, M. J., Gil, A. & Suárez, A. 2013. The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation. British Journal of Nutrition, 109 (3), pp. 394-401. DOI: 10.1017/S0007114512001298
Calvo-Irabien, L. M., Yam-Puc, J. A., Dzib, G., Escalante-Erosa, F. & Peña-Rodriguez, L. M. 2009. Effect of Postharvest Drying on the Composition of Mexican Oregano (Lippia graveolens) Essential Oil. Journal of Herbs, Spices & Medicinal Plants, 15 (3), pp. 281-287. DOI: 10.1080/10496470903379001
Chang, H. J., Kim, J. M., Lee, J. C., Kim, W. K. & Chun, H. S. 2013. Protective effect of β-caryophyllene, a natural bicyclic sesquiterpene, against cerebral ischemic injury. Journal of Medical Food, 16 (6), pp. 471-480. DOI: 10.1089/jmf.2012.2283
Cheng, X. R., Zhou, W. X. & Zhang, Y. X. 2014. The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model. Ageing Research Reviews, 13 , pp. 13-17. DOI: 10.1016/j.arr.2013.10.002
Gertsch, J. 2008. Anti-inflammatory cannabinoids in diet: Towards a better understanding of CB(2) receptor action? Communicative & Integrative Biology, 1 (1), pp. 26-28. DOI: 10.4161/cib.1.1.6568
Gertsch, J., Leonti, M., Raduner, S., Racz, I., Chen, J. Z., Xie, X. Q., Altmann, K. H., Karsak, H. & Zimmer, A. 2008. Beta-caryophyllene is a dietary cannabinoid. PNAS, 105 (26), pp. 9099-9104. DOI: 10.1073/pnas.0803601105
Hartsel, J. A., Hades, J., Hickory, B. & Makriyannis, A. 2016. Chapter 53 - Cannabis sativa and Hemp. Nutraceuticals, 2016 , pp. 735-754. DOI: 10.1016/B978-0-12-802147-7.00053-X
Jirovetz, L., Buchbauer, G., Ngassoum, M. B., Geissler, M. 2002. Aroma compound analysis of Piper nigrum and Piper guineense essential oils from Cameroon using solidphase microextraction-gas chromatography, solid-phase microextraction-gas chromatography-mass spectrometry and olfactometry. Journal of Chromatography A,976 (1-2), pp. 265-275. DOI: 10.1016/S0021-9673(02)00376-X
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